Fetal microchimerism and autoimmune disease
نویسندگان
چکیده
منابع مشابه
[Fetal microchimerism and autoimmune disease].
Microchimerism is defined by the presence of circulating cells, bi-directionally transferred from one genetically distinct individual to another. The acquisition and persistence of fetal cell microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Some of the autoimmune diseases that show a predilection...
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Fetal microchimerism occurs in normal human reproduction and is a relatively new discovery in biology. Recent data in the scientific and medical literature indicates that some of the autoimmune diseases that show a predilection for women in their child-bearing years and beyond are linked to fetal microchimerism from previous pregnancies. The pathological role of fetal microchimeric progenitor i...
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The persistence of fetal stem cells with multilineage potential in women who have been pregnant, a phenomenon known as fetal microchimerism, is emerging as a potential contributing factor in certain diseases, including cancer. For example, fetal microchimerism has been implicated in autoimmune disease, wound healing, and cancer. Studies of this phenomenon may provide a novel perspective on canc...
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Fetal microchimerism (FMc) describes long-term persistence of small numbers of fetal-derived allogeneic cells in the mother. Although FMc has been implicated as a mechanism of autoimmune disease, it may confer a beneficial effect with immune surveillance of malignant cells. We hypothesized that allogeneic FMc imparts a protective effect against breast cancer. Two observations provided a rationa...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 2010
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.33.293